Department of Laboratory Medicine, School of Medicine;
Graduate school of biomedical science and engineering,
Hanyang University
EDUCATION:
Ph.D. in Medical Science,Hanyang University, Seoul, Korea
M.S. in Medical Science, Hanyang University, Seoul, Korea
M.D., Hanyang University College of Medicine, Seoul, Korea
PROFESSIONAL EXPERIENCE:
Present: Professor of Lab Med of Hanyang Univ. Medical college
Associate prof. of Lab Med of CHA Univ. Medical college
Clinical and research associate prof. of Lab Med at Yonsei Univ.
Severance Hospital
Clinical and research fellow of Lab Med at Yonsei Univ.
Severance Hospital
Clinical and research fellow of Lab Med at Hanyang Univ. Hospital
Residency of Laboratory Medicine at Hanyang University hospital
Internship at Hanyang University Hospital
Articles published in peer-reviewed journals:
Stroma-free mass production of clinical-grade red blood cells (RBCs)
by using poloxamer 188 as a RBC survival enhancer.
Baek EJ, Kim HS, Kim JH, Kim NJ, Kim HO.Transfusion 2009;49:2285-95.
Reduction of the Platelet Transfusion Dose and Its Effects.
Baek EJ, Lee YS, Kim HS, Bae IC, Kim HO. Korean J Lab Med
2009;29:158-62.
Two-step maturation of immature DCs with proinflammatory cytokine cocktail
and poly(I:C) enhances migratory and T cell stimulatory capacity.
Kim HJ, Kim HO, Lee KW, Baek EJ, Kim HS. Vaccine 2010;28:2877-2886
Enhanced production of RBCs in suspension by electrostatic interactions
with culture plates. Baek EJ, You J, Kim MS, Lee SY, Cho SJ, Kim HO, Kim E.
Tissue engineering Part C 2010;16:1325-34.
Direct and Differential Effects of Stem Cell Factor on the Neovascularization
Activity of Endothelial Progenitor Cells. Kim KL, Meng Y, Kim JY, Baek EJ,
Suh W. Cardiovascular Research 2011;92:132-140.
Red blood cell engineering in stroma and serum/plasma-free conditions and
long term storage. Kim HO, Baek EJ Tissue engineering Part A. 2012;18:117-26.
Hemolytic disease of newborn due to anti-Jka and the duration of antibody
persistence. Baek EJ , Park SC, Kwon YH, Kim CR. Journal of Paediatrics and Child Health 2013:16;49:E101-2.
Genomic breakpoints and clinical features of MLL-TET 1rearrangement in
acute leukemias. Lee SG, Cho SU, ,,, Park TS, Baek EJ.
Haematologica 2013;98:e55-57.
Autonomous control of terminal erythropoiesis via physical interactions
among erythroid cells. Choi HS, Lee EM, Kim HO, Park MI, Baek EJ.
Stem Cell Research. 2013;10:442-453
De novo hairy cell leukemia with a major BCR/ABL1 rearrangement:
a case report with a literature review. Won YW, Kim SJ, Park TS,
Oh SH, Wan TS, Baek EJ. Pathology International 2014;64:142-7.
The RNA in reticulocytes is not just debris: it is necessary for the final
stages of erythrocyte formation. Lee EM, Choi HS, Hwang JH, Hoh JK,
Cho YH, Baek EJ
Blood Cells, Molecules and Diseases. 2014;53:1-10.
Red blood cell generation by three-dimensional aggregate cultivation of
late erythroblasts. Lee E, Han SY, Choi HS, Chun B, Hwang B,
Baek EJ. Tissue engineering Part A 2015;21;817-828.
Artificial blood: from the past to the future Choe WH,Baek EJ.
ISBT Science Series 2015;10:150-153.
Rh D blood group conversion using transcription activator-like effector
nucleases. Kim YH, Kim HO, Baek EJ, Kurita R, Cha HJ, Nakamura
Y, Kim H. Nature communications 2015;6:7451
Macrophages and PMA-stimulated macrophage-like cells express
the erythroid cell-lineage adhesion molecule, ICAM-4:Implications for
generation of erythrocytes in vitro. Choi HS, Baek EJ. Cytotherapy
2017;19:1248-1250.
Cell sources for large-scale manufacture of red blood cells.
Kim, S, Baek EJ. ISBT science series 2018:13;268-273
The effects of plasma gelsolin on human erythroblast maturation for
erythrocyte production. Han SY, Lee EM, Choi HS, Chun BH,Baek
EJ. Stem Cell Res. 2018;29:64-75.
Mbd2-CP2c loop drives adult-type globin gene expression and definitive
erythropoiesis. Kim MY, Kim JS, Son SH, Lim CS, Eum HY, Ha DH,
Park MA, Baek EJ, Ryu BY, Kang HC, Uversky VN, Kim CG.
Nucleic Acids Res. 2018;46:4933-4949
A case of doxycycline-induced false-negative results of malaria rapid
antigen testing. Lim JH, BaekEJ. Laboratory Medicine Online 2019 July
Improvement of Red Blood Cell Maturation in vitro by serum-free medium
optimization Kim SH, Lee EM, Han SO, Choi HS, Ryu KU, BaekEJ
Tissue engineer part c methods 2019;25:232-242CRISPR/Cas9 PIG-A
Gene Editing in Non-Human Primate Model Demonstrates No Intrinsic
Clonal Expansion of PNH HSPCs. Baek EJ, Shin TH, Corat MAF, Chen S, Metais JY, Aljanashi AA, Zhou Y, Donahue RE, Yu KU,Dunbar CE. Blood 2019 Apr 19 [Epub ahead of print]
<Books>
1) Baek EJ: Blood. in You J. &
Lee IU. Regenerative medicine. 3rd ed.
(original edition)
Hematopoietic Stem Cells, in H. W. Kim and A. G. Greenburg (eds):
Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen
Therapeutics, Berlin: Springer Berlin Heidelberg, 2013, Chapter No.
20
(Online ISBN: 978-3-642-40717-8,
Print ISBN: 978-3-642-40716-1) (original edition)
3) Baek EJ: artificial blood. Blood. 3rd ed. Seoul: Bum-Moon education,
2018. Chapter 52. ISBN 10:
1159431000,
ISBN 13: 9791159431005) (original edition)
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Description of the lab : research for hematopoiesis, manufacturing of red blood
scale, and myelodysplasia
○ registered: Korea, south 11, USA 4, EU 3
( No.; Registered Nation; Patent Title; enrolled No.; enrolled Date )
2. Korea; Process for preparing red blood cells using positively charged surface; 10-1128262; 2012.03.13.
3. Korea; Process for preparing red blood cells in vitro using hypothermic culture condition; 10-1184919; 2012.09.17
4. Korea; Scale-up of in vitro human erythrocyte production by increased erythroblast culture density; 10-1341558; 20131209
5. Korea; Myelodysplasia reduction and artificial erythrocyte production; 10-1416954; 20140702
6. Korea; Scale-up of in vitro human erythrocyte production by increased erythroblast culture density; 10-1438533; 20140901
7. Korea; Scale up of in vitro red blood cells using high density cell culture; 10-1447902; 20140930
8. Korea; Method for red blood cell production in vitro and long-term storage; 10-1707387; 20170209
9. Korea; Diagnosis of hematologic-oncologic diseases using gelsolin; 10-1746915; 20170607
10. Korea; A peptide having anticancer activity for prevention and treatment of cancer; 10-1841339; 20180316
11. Korea; 3D culture system by erythroid cell packing for transfusable RBC generation in vitro; 10-1845588; 20180329
12. USA; Myelodysplasia reduction and artificial erythrocyte production; US9828584; 20171128
13. USA; Scale-up of in vitro human erythrocyte production by increased erythroblast culture density; US9834752; 20171205
14. USA; 3D culture system by erythroid cell packing
for transfusable RBC generation in vitro; US10273455; 20181214
15. USA; diagnosis of hematological malignancies; 10,161,006; 20181225
16. EU; diagnosis of hematological malignancies; Registered;
20181017
17. EU; Method for in vitro expansion of erythroid cells; EP2896689; 20190410
18. EU; Scale-up of in vitro human erythrocyte production by increased erythroblast culture density; registered; 20190325
(No. ; Applied Nation; Patent Title; Applied No. ; Applied date)
2. Korea; 3D culture system by erythroid cell packing
for transfusable RBC generation in vitro; 10-2014-0041320; 20140407
3. Korea; Establishment of immortalized erythroblast cell lines for erythrocyte production; 10-2018-0068692; 20180615
4. Korea; Process for automatic harvesting mature red cells from culture systems; 10-2018-0167570; 20181221
5. Korea; Production of red cells using bioreactors; 10-2019-0003098; 20190110
6. UK; Myelodysplasia reduction and artificial erythrocyte production using gelsolin; GB 13836414.6; 20190514